That's a good point. Claim your 100% free Doctor.com profile to: All the studies that use the two, three weeks schedule, and we just have to go by what basis was for changing the dosing. Frayed Geographies and Fractured Selves: Shilpa Gupta’s Untitled (2014-15) Iftikhar Dadi My East is Your West, Essay, 2016 So the trials that are ongoing are pembrolizumab followed by cystectomy, versus cystectomy alone, in cisplatin-ineligible patients. Is that a dose that you're now using across all patients or in selected patients? Another trial is looking at nivolumab in these patients. Please enter a valid 5-digit Zip Code. View phone numbers, addresses, public records, background check reports and possible arrest records for Shilpa Gupta in Maryland (MD). So you mentioned obviously pembro has moved to 400 every six weeks. Shilpa Gupta: Yes. But I think in the community, I foresee that it may be interchangeable because pembrolizumab is given every six weeks and it's more convenient. Contact to request or schedule an appointment today! While she points out that IMvigor010, testing adjuvant atezolizumab versus observation in high risk muscle-invasive urothelial carcinoma, had negative results, she also discusses the positive results of the JAVELIN 100 study of maintenance immunotherapy for metastatic urothelial cancer which led to the United States Federal Drug Administration (FDA) approval of maintenance avelumab. It will remain to be seen if this will become an approved option. Dr. Shilpa Gupta graduated from Other in 2001. Scroll to top In fact, it was presented last year at ASCO. Then the NIAGRA trial is looking at Gem/Cis plus durvalumab, versus Gem/Cis. fax: (513) 636-7486. This was a study of preoperative ipilimumab and nivolumab in stage III urothelial cancer. Dr. Gupta graduated from the Dr B R Ambedkar Medical College in 1999. Dr. There's a lot going on in the bladder cancer field, and I'm delighted to share the key updates. She surveys other trials presented at the 2020 ASCO meeting, including KEYNOTE-866 for cisplatin eligible patients, and IMvigor010 on adjuvant immunotherapy approaches. Having more than 15 years of diverse experiences, especially in INTERNAL MEDICINE, Dr. Shilpa Gupta affiliates with many hospitals including Baylor Scott & White Medical Center - Centennial, Baylor Scott & White Medical Center Plano, Baylor Scott & White The Heart Hospital - Plano, cooperates with many other doctors and specialists in medical group Healthtexas Provider Network. But we are making sure we check in with them virtually at three weeks to make sure they don't have any subtle side effects, which need to be worked up. So this is the study design, any patient who got first-line platinum-based chemotherapy, either carboplatin or cisplatin, and did not have progressive disease, was enrolled in this study, was eligible, with unresectable locally advanced or metastatic urothelial cancer. Locations {{locAOne}} {{locATwo}} {{locHrMsg}} More Hours---LOCATION DETAILS. Ashish Kamat: And then based on all the data that's been presented, in 2020 to date, it's been a crazy year, but a lot of data coming out. About Shilpa Gupta MD Dr. Gupta graduated from the Lady Hardinge Medical College in 2001. You know, right now that is a setting where we know immunotherapy works, but there is no substantially randomized trial data. I appreciate the opportunity. Dawn E. Dolan, Pharmd and Shilpa Gupta, MD. The disease-free survival was similar in both the groups, it was not significantly different. How have you modified your counseling of patients that present to you at the different stages of bladder cancer? What are you most excited about? Dr. Gupta is affiliated with James A Haley Veterans Hospital and … Dr. Shilpa Gupta, MD is a Medical Oncology Specialist in Tampa, FL. And the primary endpoint was feasibility, which is a key concern in these patients. Find Dr. Gupta's phone number, address, insurance information, hospital affiliations and more. Stratification was based on the response to first-line chemotherapy and metastatic sites, that is visceral versus non visceral. An official Page. Starting with results from the NABUCCO trial of neoadjuvant immunotherapy options in stage III urothelial cancer, Dr. Gupta highlights the results from … This table primarily outlines the fact that it is looking encouraging and doable with no delays to cystectomy in majority of patients and encouraging responses in both cisplatin-eligible, as well as cisplatin-ineligible patients. So that would actually be similar then to about 24, 25%. Of note, the other trials in this space did not have a mandatory biopsy and the FDA mandated a futility analysis after 25 eligible CIS patients reached the six-month endpoint. According to Gupta, preliminary safety data is needed for triplet regimens in RCC. She graduated with honors in 2005. First-year MBA student at University of Maryland’s Smith School of Business with a focus on marketing and product management. Female. And then, in moving back to the other studies that you mentioned. Please verify insurance information directly with your doctor’s office as it may change frequently. About. And the other promising option is the intravesical INSTILADRIN which showed 53% three-month complete response rate, in high grade, BCG-unresponsive CIS positive patients. Shilpa Gupta, 38 Rockville, MD. Advanced Prostate Cancer Consensus Conference (APCCC), American Society of Clinical Oncology (ASCO), ANZUP Mini Annual Scientific Meeting (ASM), European Society for Medical Oncology (ESMO), International Bladder Cancer Network (IBCN), Society of Nuclear Medicine and Molecular Imaging (SNMMI), Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU), World Congress of Endourology and SWL (WCE), A Step Towards Personalized Medicine: PSMA PET Imaging in Prostate Cancer, Contemporary Treatment Strategies For Androgen Deprivation Therapy In Prostate Cancer, COVID-19 and Genitourinary Cancers Videos, Large Urology Group Practice Association (LUGPA), Precision Medicine: PSMA Targeted Therapies in Progressive Metastatic Prostate Cancer Videos, Advances in Nuclear Medicine, PET, and Theranostics, Cardiovascular Disease in Men with Prostate Cancer, Nocturia & Lower Urinary Tract Conditions, ASCO 2020: Biomarker Analysis and Updated Clinical Follow-Up Of Preoperative Ipilimumab Plus Nivolumab in Stage III Urothelial Cancer (NABUCCO), ASCO 2020: JAVELIN Bladder 100 Phase III Results: Maintenance Avelumab + Best Supportive Case vs BSC Alone After Platinum-Based First-Line Chemotherapy in Advanced Urothelial Carcinoma, JAVELIN Bladder 100: Results of First-line Maintenance Therapy Plus Best Supportive Care Demonstrates Significant Prolonged OS in Advanced Urothelial Cancer - Cora Sternberg, IMvigor010 Primary Analysis from a Phase III Randomized Study of Adjuvant Atezolizumab versus Observation in High-Risk Muscle-Invasive Urothelial Carcinoma - Thomas Powles & Matthew Galsky. Internal Medicine ,Hematology/Oncology , Medical Oncology and Urological Surgery (866) 720-2869. Genitourinary Oncologist, Department of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio Dr. Shilpa Gupta is a genitourinary oncologist with a research focus on clinical and translational research in genitourinary cancers. Her mediums range from manipulated found objects to video, interactive computer-based installation and performance. Internal Medicine ,Hematology/Oncology , Medical Oncology and Urological Surgery Thanks for the opportunity for sharing the key ASCO updates. So with that, Dr. Gupta, take it away. She works in Cleveland, OH and specializes in Genitourinary. It was a Phase II trial, and it's not FDA approved in this setting. So I think going by the mechanism and the pharmacokinetic dose distribution data, it's safe to say that it's probably okay to use the six weeks study. She has 21 years of experience. Genitourinary Oncologist, Department of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio Dr. Shilpa Gupta is a genitourinary oncologist with a research focus on clinical and translational research in genitourinary cancers. What does your discussion with them look like now? She has indicated that she accepts telehealth appointments. Shilpa Gupta, MD, discusses ongoing research with immunotherapy in bladder cancer, where research efforts should focus with regard to biomarkers, and … Shilpa Gupta. Her credentials are: MD, MBBS.She lists the following medical group affiliations: Fairview Health Services.Her hospital privileges include: University Of Minnesota Medical Center, Fairview. Dr. Shilpa Gupta, MD is a Pediatrics Specialist in Cincinnati, OH. So I'm thinking maybe we do need some tumor burden for the immunotherapy to work in bladder cancer. This webpage represents 1548455355 NPI record. Dr. Shilpa Gupta MD is Dentist in Riverside. Starting with results from the NABUCCO trial of neoadjuvant immunotherapy options in stage III urothelial cancer, Dr. Gupta highlights the results from the trial showing complete responses in 46% of patients. What do you suppose the biologic rationale would be for IMvigor010 being a negative study, and JAVELIN-100, even though it's obviously different patient populations, they're in the spectrum of the disease. Ashish Kamat: Welcome everybody to UroToday's Bladder Cancer Center of Excellence. Could you postulate your hypothesis as to why one was positive and one might have been negative, and how the audience should interpret the data? If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Shilpa Gupta , MD. Dr. Shilpa Gupta is an Internal Medicine Specialist in Garland, Texas. Shilpa Gupta, MD presents data from ASCO 2020 on bladder cancer in this discussion with Ashish Kamat, MD, MBBS. While in the maintenance setting, these patients started out with metastatic disease, and most of them had some residual disease at the time of enrollment. But if he were to follow level one evidence, I think the label is only for avelumab, and that is what we should stick to when possible. So for patients who are presenting with metastatic urothelial cancer, we offer platinum-based chemotherapy to all where we can. Dr. Gupta graduated from the Lady Hardinge Medical College in 2001. And in the PD-L1 positive population, the results were even more pronounced. Have you gone to six weeks for everybody for pembro? We also participated in the pembrolizumab Hoosier study led by Dr. Matt Galsky, which also utilized the switch maintenance approach. Do you have any concerns or any words of caution for people that are extrapolating results from one study to a different dosing schedule? Be sure to call ahead with Dr. Gupta to book an appointment. And the primary analysis populations were all intention-to-treat patients, as well as PD-L1 positive population. Dr. Shilpa Gupta The combination of nivolumab with gemcitabine and cisplatin in the neoadjuvant setting was well tolerated and resulted in promising pathologic response rates in patients with muscle-invasive bladder cancer (MIBC), according to results of the phase II BLASST-1 study (Abstract 439). She works in Cleveland, OH and specializes in Genitourinary. The key study that was presented at ASCO this year was the IMvigor010. Get the WebMD Daily newsletter for health tips, wellness updates and more. https://www.dupagemedicalgroup.com/physicians/shipra-gupta-md Dr. Shilpa Gupta is an Angel walking on this earth to my wife and I. 2,792 likes. Specialty Endocrinology / Diabetes Pediatrics Pediatric Endocrinology Shilpa Gupta: Six-week dosing. A quick question about the dosing schedule. So it did not meet the primary endpoint. Moving on to adjuvant immunotherapy approaches in muscle-invasive bladder cancer. Shilpa Gupta: ‘The current moment shows we are closer than we imagined’ Vandana Kalra, Indian Express, 6 September 2020. WebMD does not provide medical advice, diagnosis or treatment. Cleveland Clinic Main Campus 9500 Euclid Avenue Cleveland , OH 44195. Are you Dr. Gupta? Today, she's going to join us and present to us key updates from ASCO 2020, and then we'll have a brief discussion on what Shilpa thinks are some of the highlights of the presentations. © 2005 - 2021 WebMD LLC. 44 patient ratings, 5 patient comments Specialties. Stay safe, stay well, and hopefully, we'll actually see each other in person sometime soon. Are you Dr. Shilpa Gupta, MD? I'm Ashish Kamat from Houston, at MD Anderson Cancer Center. Shilpa Gupta , MD. They also looked at several biomarkers, like tumor mutational burden, intratumoral TDH, and TGF data associated genes. Shilpa Mehra, M.D., F.A.C.G. Dr. Shilpa Gupta, MD is a Pediatrics Specialist in Cincinnati, OH. Correct. SHARE | PRINT . This website uses cookies to ensure you get the best experience on our website. I think that would be what I'd be most excited about. The 1548455355 NPI number is assigned to the healthcare provider SHILPA GUPTA MD, MBBS, practice location address at 909 FULTON ST SE MINNEAPOLIS, MN, 55455-4800. Learn about Dr. Shilpa Gupta, an internist & hematologist / oncologist in Tampa, FL & Minneapolis, MN. Cincinnati Children's Hospital Medical Center Fellowship, Pediatric Endocrinology, 2005 … This is Me - Control Profile. So we still keeping a close eye on the patients, but the dosing is every six weeks for all the patients. The ongoing Phase 3 neoadjuvant trials will certainly help us establish immunotherapy as a backbone in this setting. Dr. Shilpa Gupta is a Internist in Plano, TX. Sign Up to Receive Our Free Coronavirus Newsletter, Leave Next is the maintenance immunotherapy setting in metastatic urothelial cancer. School of Fine Arts in 1997. She has been in practice between 11-20 years. Correct. She graduated from medical school in 2001 and has 19 years of diverse experience with area of expertise as Hematology/oncology. And very encouraging clinical results were shown: complete responses in 46% patients, and down-staging in around 58% of patients. I have a couple of questions for you. And at this point, I would also like to mention that the first-line trials of combination chemotherapy and immunotherapy have been negative so far, and maintenance immunotherapy seems to be the way to go. With overall survival, not reached in avelumab and best supportive care arm, and 17 months in the best supportive care arm. Correct? She guided my wife's treatment after Cancer Surgery, and we are blessed to say she is in remission now for two years. Stay safe. Shilpa Gupta, MD. Are you Dr. Gupta? 469.764.8000. And there was one patient that had rapid progressive disease and died from that. She is affiliated with Riverside Community Hospital. View Shilpa's age, phone number, home address, email, and background check information now. Patients received ipilimumab loading dose, followed by Ipi Nivo, and one dose of nivolumab. Dr. Shilpa Gupta, MD is a Pediatrician (Kids / Children Specialist) - Pediatric Endocrinology practicing in Cincinnati, OH She has not yet shared a personalized biography with Doctor.com. - NJ Gastroenterologist at GANJ Simply select your manager software from the … Dr. Gupta is a genitourinary oncologist and the Lead for the Phase 1 Interdisciplinary Solid Tumor Program at the Masonic Cancer Center. I have gone to six weeks, especially with the COVID logistics. Most patients received all three cycles, and immune-related adverse events did occur in around 54% of patients. This was a single-arm Phase II trial with BCG-unresponsive, high risk, non-muscle-invasive bladder cancer patients. In the rare circumstance where they cannot get carboplatin, we treat them with single-agent immunotherapy, or if they have high PD-L1 expression in their tumors, and they are cisplatin-ineligible, then they also meet the criteria. It was determined by mandatory biopsy. Request Appointment. Shilpa Gupta: No, I think, you're right. But we do present that to our patients, and if they're good candidates, that is the level one evidence that we are following right now. The key data that was presented at this meeting showed that at a followup from 15.9 months, only about 8% of patients had relapsed. Photos | Summary | Follow. Now, as you know, it's every two weeks, that's a lot of commitment for the patients, who are especially traveling from long distances. Starting with results from the NABUCCO trial of neoadjuvant immunotherapy options in stage III urothelial cancer, Dr. Gupta highlights the results from … Dr. Shilpa (Dewan) Gupta, MD is a pediatric endocrinologist in Riverside, California. Hindi. Unfortunately, this was a negative trial, as we can see here. Find Dr. Gupta's phone number, address, insurance information, hospital affiliations and more. It's always a pleasure chatting with you, and thanks for taking the time and sharing your thoughts and the updates with our audience. And the ENERGIZE trial is looking at it Gem/Cis and nivolumab, plus-minus IDO inhibitor, versus Gem/Cis alone. Please click the button below to report on a patient with cancer and COVID-19. It showed progression-free survival benefit with pembrolizumab compared to placebo. About Dr. Shilpa Gupta (Dewan), MD Dr. Shilpa Gupta (Dewan) is a pediatric endocrinologist in Riverside, California and is affiliated with one hospital. If you take this last slide that you still have up, for example, you're showing that the CR rate at 12 months was 45.5%, but that's 45.5% off the 53% at three months. Great. As we have also enacted with nivolumab, all original studies were every two weeks, but we are using the flat dose every four weeks. Dr. Shilpa Gupta is an Angel walking on this earth to my wife and I. I'm sorry. The AMBASSADOR trial is comparing pembrolizumab versus observation in high-risk muscle-invasive bladder cancer, or upper tract disease. The only difference from the IMvigor trial is that this does allow positive margins, IMvigor010 did not. 4.9. Shilpa Gupta, MD Dr. Shilpa Gupta is a genitourinary oncologist at the Cleveland Clinic Taussig Cancer Institute in Cleveland, Ohio. And as we can see, the overall survival was significantly better with avelumab and best supportive care alone. Dr. Gupta is affiliated with Riverside Community Hospital and Parkview Community Hospital Medical Center. Shilpa Gupta, MD. In the overall population, it was 3.7 months in avelumab arm, versus two months in best supportive care arm. And these were high-risk cisplatin-ineligible patients. Breakthroughs in Bladder Cancer Research | Cleveland Clinic She works in Riverside, CA and specializes in Endocrinology, Diabetes & Metabolism and Pediatric Endocrinology. How Long Does Coronavirus Live On Surfaces? The CHECKMATE-274 trial is again, similar setting, randomization to nivolumab versus observation, and the primary endpoint is disease-free survival in PD-L1 positive patients and all patients. This was the primary analysis from the Phase III randomized trial of adjuvant atezolizumab versus observation in high risk muscle-invasive urothelial carcinoma. OVERVIEW. Shilpa Gupta: Yeah, that's an interesting question, Ashish. This is the study's schema, it did not meet the primary piece specified endpoint, but interestingly, the three month CIS patient complete response rate was 42%. 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For pembro College in 2001 lot going on in the overall population, and IMvigor010 on immunotherapy..., Newsletter preferences and use bookmarks was established ASCO meeting, including KEYNOTE-866 for cisplatin eligible patients, there. Presented in Tom Powles ' study Newsletter preferences and use bookmarks in Matrix! Cancer Institute in Cleveland, OH in 46 % patients, but shilpa gupta, md dosing every. About 24, 25 Jul 2018 to report on a patient with cancer and COVID-19 other IO agent in intention-to-treat. Across all patients or in selected patients different stages of bladder cancer ‘... Out to her office ( for appointments etc. NABUCCO, that 's what failed to get a.! Subscriptions at any time situ, plus-minus Ta/T1 data was presented - West Bank Campus disease-free..., interactive computer-based installation and performance I should have clarified that on this earth my! 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