She then joined as faculty in the Division of Hematology, Oncology and Transplantation at the Masonic Cancer Center, University of Minnesota in Minneapolis where she also led the Interdisciplinary Solid Tumor Phase 1 Program until June, 2019 prior to joining the Cleveland Clinic. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. That was a phase II trial. DC USA So we are developing something with atezolizumab and cabozantinib, which is a VEGF-inhibitor. As you noted, this is a Bladder Cancer Signal Seeking Trial I. Yeah. Hematology-Oncology Milwaukee, You will find additional podcast episodes on our website, clevelandclinic.org/canceradvancespodcast. Shilpa Gupta, MD: Yes. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. View the profiles of professionals named "Shilpa Gupta" on LinkedIn. Typically, I try to reach out to the ones I know personally to see if they have patients to refer to us. Not every place has all these good combinations. Patients received four cycles of gemcitabine and cisplatin with nivolumab added on day eight of each cycle. We are thinking of coming up with a chemo plus immunotherapy trial, just for small cell bladder cancer patients, even though it is rare. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. She is the author for the AUA core curriculum for penile cancer. But we want to develop something in small cell with our colleagues like Dr. Omar Mian from rad-onc, who has interest in that as a basic scientist. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Shilpa Gupta und … Thank you for listening. Our goal is to develop novel agents in combination with chemo and immunotherapy trials. This is really a nice segue to validate these findings in a randomized fashion. More importantly, the combination was very safe with no increased toxicities from the combination. Yes, absolutely. She's here today to discuss clinical trials in bladder cancer. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. Dale Shepard, MD, PhD: How are you taking the findings of that and transferring that here to what you're doing here at Cleveland Clinic? You will find additional podcast episodes on our website, clevelandclinic.org/canceradvancespodcast. Im Profil von Shilpa Gupta sind 3 Jobs angegeben. Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Because in upper tract it's found that fibroblast growth factor receptor is expressed up to 70 to 80% patients. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education. She also serves as the ASCO University Review Panel Member and ASCO Daily News/Podcast Sources Member and on the ASCO Item Writing Workshop. It's an exciting place to be, and we are doing some really nice work in this field. Yes. So we did this multi-institutional study across three sites, University of Minnesota, Dana-Farber and University of Utah. Yeah, and I think the key is just being available, so if people call or send an email and ask if we have something available, to reach out and collaborate with people, so I think that helps. We wanted to see if adding immunotherapy to this chemotherapy combination can enhance pathologic responses and survival outcomes, as immunotherapy is widely used in metastatic disease with a great response rate and outcomes. Dr. Shilpa has 3 jobs listed on their profile. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. Shilpa Gupta, MD: Thanks, Dale. * In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry. Well, there really are a lot of exciting things going on in bladder cancer, and I appreciate you highlighting them for me. Don't forget, you can access real-time updates from Cleveland Clinic's Cancer Center experts on our Consult QD website at consultqd.clevelandclinic.org/cancer. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. We found that pathologic down staging occurred in 66% patients and complete responses were seen in 49% patients. What about the more unusual histologies? I think the big plus here is the patient volume we have the opportunity to put on files. So these results were very promising, overall. The primary end-point was pathologic down staging to PT1 or below at surgery, and the study was aimed at achieving at least 45% at cystectomy. But are there going to be other trials that you're looking into with similar approaches to offer to patients, or what does the landscape look like? CORONAVIRUS: DELAYS FOR ROUTINE SURGERIES, VISITOR RESTRICTIONS + COVID-19 TESTING. shilpa has 1 job listed on their profile. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. As you noted, this is a Bladder Cancer Signal Seeking Trial I. Shilpa, can you tell me a little bit about your role here at Cleveland Clinic? View Shilpa Gupta Solanki’s profile on LinkedIn, the world’s largest professional community. That's an excellent question, Dale. Shilpa has 4 jobs listed on their profile. Today, I'm happy to welcome Dr. Shilpa Gupta, a member of our Taussig GU program. Shilpa has 8 jobs listed on their profile. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. Shilpa has 1 job listed on their profile. Not every place has all these good combinations. It was pretty remarkable. This was an investigator-initiated trial that I led. 2009, Fellowship - Georgetown University School of Medicine What have you found, and how have you managed to offset their concerns? So thanks so much for joining us today. 2007, Internship - RCH Government Hospital But we do see quite a handful over a year, so I think it's worth an multi-institutional effort we need to look at. Apple Podcasts    |    Google Podcasts    |    SoundCloud    |    Spotify    |    Blubrry    |    Stitcher. Those are some of the other directions we're taking in other settings like cisplatin-ineligible setting. You mentioned upper tract disease, and so certainly one of the things we see a lot here at Cleveland Clinic are rare diseases and that's kind of a focus is seeing people who may have more unusual types of cancer. After cystectomy, patients would continue immunotherapy if they are on those arms. Subscribe:    Thanks for the opportunity. Shilpa has 6 jobs listed on their profile. CT USA Dale Shepard, MD, PhD: You mentioned upper tract disease, and so certainly one of the things we see a lot here at Cleveland Clinic are rare diseases and that's kind of a focus is seeing people who may have more unusual types of cancer. Shilpa has 8 jobs listed on their profile. Can you maybe tell us a little bit about that study and about the findings and what you told everyone about? Certainly this is a trial that's going to answer some important questions, and we won't exactly know this answer for a while. Thanks, Dale. She has led several early and late phase clinical trials, including investigator-initiated trials using novel targeted therapies and immunotherapies in genitourinary cancers. Shilpa Gupta, MD: Yes, absolutely. Shilpa Gupta, MD: The key, I think, was a great multi-disciplinary team effort. View Shilpa Gupta Yadav’s profile on LinkedIn, the world’s largest professional community. As of 1/6/2021, Dr. Gupta has reported no financial relationship with industry that is applicable to this listing. Shilpa has 7 jobs listed on their profile. Shilpa has 6 jobs listed on their profile. View the profiles of professionals named "Shilpa Gupta" on LinkedIn. Our patients here know that in any case, even if they don't go on a trial, 12 weeks of chemotherapy is standard, and after that, within six to eight weeks, they get operated upon. All patients received all the four cycles, except for two patients who received only two cycles. She also provides an update on additional in-progress clinical trials and what’s on the horizon for bladder cancer research. Dale Shepard, MD, PhD: Yeah, and I think the key is just being available, so if people call or send an email and ask if we have something available, to reach out and collaborate with people, so I think that helps. Dale Shepard, MD, PhD: How about patients? In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. All the urology colleagues, radiation oncology colleagues, Dr. Mian, who actually is leading another Department of Defense TTSA grant this year, and I'm the co-PI on that along with Dr. Tae Hyun Wong and are a really vibrant group of research personnel and colleagues. We have the cohort of our trial, the BLASST-1, which is immunotherapy and chemotherapy and Dr. Peter Black, who's a collaborator from Vancouver, he has a cohort of his patients who received only gem-cis chemotherapy and Dr. Andrea Necchi from Italy has done single-agent pembrolizumab trial in the same setting. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. It's quite exciting. * Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. That is something our urologists here at Glickman are very excited about and are referring patients for that. Dr. Gupta’s primary research interests are in genitourinary cancers, with a focus on bladder and prostate cancer. But I think as an institutional-wide effort, it would be good to have a disease-specific flyer go out to these. Dale Shepard, MD, PhD: Well, there really are a lot of exciting things going on in bladder cancer, and I appreciate you highlighting them for me. 2008, Residency - University of Connecticut Health Center Any keys to involving all the patients that are being seen in our regional practices? It does seem to be a common question, doesn't it? Dr. Tae Hyun Hwang from the Lerner Research Institute is a collaborator on that grant as well. Shilpa Gupta, MD: Yes, absolutely. Dr. Gupta obtained her Medical Degree at the Lady Hardinge Medical College in New Delhi, India and completed a residency in Internal Medicine at the University of Connecticut Health Center. Shilpa Gupta, MD: Yes, absolutely. As you know, most of these bigger trials usually exclude small cell cancers, even though they allow other histologies, as long as there's some urothelial cancer present. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant. We wanted to see if adding immunotherapy to this chemotherapy combination can enhance pathologic responses and survival outcomes, as immunotherapy is widely used in metastatic disease with a great response rate and outcomes. Hematology-Oncology Philadelphia, BMS is doing a phase III randomized trial, which we are involved in with the protocol development, so that's called the ENERGIZE trial. Have a great day. Sehen Sie sich das Profil von Shilpa Gupta im größten Business-Netzwerk der Welt an. Please join us again soon. But we do. Are they leery to enroll in trials that delay surgery? Summary: shilpa dasgupta is 44 years old and was born on 08 01 1976. shilpa dasgupta currently lives in foster city, ca; in the past shilpa has also lived in thornton co and cedar park tx. Our other two sites, which participated, again, had great urology and med-onc team. No, that's a very valid concern, and in our phase II trial, we showed that there were no delays to surgery. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. We currently have that open at Cleveland Clinic. Yes, I joined Cleveland Clinic last year in June from University of Minnesota, and my role here is to lead the bladder cancer program. I find within my short time here, the time to opening trials is improving as we go and I think you would agree with that. But we do see quite a handful over a year, so I think it's worth an multi-institutional effort we need to look at. Right now we want to see how best to achieve pathologic down staging in those patients. BMS is doing a phase III randomized trial, which we are involved in with the protocol development, so that's called the ENERGIZE trial. View Dr. Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. I think that is the key we learned, that by the time patients progress, it is too late, so how to intensify treatments early on. Dale Shepard, MD, PhD: It does seem to be a common question, doesn't it? Dr. Gupta shares data from the phase II Bladder Cancer Signal Seeking Trial (BLASST-1), recently presented at the American Society of Clinical Oncology’s Genitourinary Cancers Symposium. What's next? Public Health Service-Reportable Financial Conflicts of Interest. There are 10 professionals named "Shilpa Gupta", who use LinkedIn to exchange information, ideas, and opportunities. It's a multi-arm trial with the gem-cis as the control arm, and the other two arms have gem-cis and nivolumab and gem-cis-nivolumab plus IDO inhibitor. Certainly people who might be listening may not be associated with a larger institution, and they may be needing to partner with somebody to send patients. What do you think is the biggest key to building what has become a really robust bladder cancer research program here at Cleveland Clinic? What about things in an adjunct setting, can you tell me a little bit about what we're doing in that setting? See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. 2011, Fellowship - Jefferson Medical College of Thomas Jefferson University To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page. Based on these findings, this is the only phase II trial, which has shown that nivolumab is safe with chemotherapy. Is there any particular thing you're looking forward to? No, that's a very valid concern, and in our phase II trial, we showed that there were no delays to surgery. There are 600+ professionals named "Shilpa Gupta", who use LinkedIn to … Shilpa Gupta, MD: Yeah. Dale Shepard, MD, PhD: I know that you've presented some preliminary results from a phase II trial, something called the Bladder Cancer Signal-Seeking Trial at the GU ASCO meeting earlier this year. It's really taking a step further by adding another immunotherapy agent. There are 700+ professionals named "Shilpa Gupta", who use LinkedIn to exchange information, ideas, and opportunities. What was the key to the success in getting this trial to happen? Certainly immunotherapy is everyone's interest still, combining with chemotherapy. 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